Part II | Chapter 8 176 Supplementary E Model 1 The full regression equation for model 1 is as follows: ℎ( ) = ℎ!( ) ∗ exp (−0.065 ∗ + 0.78 ∗ ln ( ) + 0.053 ∗ − 0.14 ∗ + 0.16 ∗ ′) Or for calculating the predicted survival probability: ( ) = !( )"#$ ('!.!)*∗,-. / !.01∗23 (45,) / !.!*7∗89: ' !.;<∗45,=9 / !.;)∗45,=9>) Where: § h(t) = the expected hazard at time t § h0(t) = the baseline hazard at time t § s(t) = the expected survival probability at time t § s0(t) = the baseline survival at time t (see Table 2 for baseline survival at 12, 24, and 36 months) § Age = age in years at time of focal salvage high-dose-rate brachytherapy § ln = natural logarithm § PSA = pre-salvage prostate-specific antigen level in ng/mL § GTV = Gross Tumour Volume in cm3 § PSADT = PSA-doubling time in months PSADT’ can be calculated as follows: ′ = ( − 7.98 )/7 − 1.43( − 15.70)/7 + 0.44( − 33.63)/7 657.9225
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