Prediction models for biochemical failure after FS-HDR-BT 177 Model 2 ℎ( ) = ℎ !( ) ∗ exp (−0.087 ∗ + 1.50 ∗ ln ( ) + 0.40 ∗ − 0.12 ∗ + 0.15 ∗ ′ − 0.20 ∗ − 0.021 ∗ % ) Or for calculating the predicted survival probability: ( ) = !( )"#$ ('!.!10∗,-. / ;.*!∗23(45,) / !.<!∗5.?@ABC D.E@FC. @ADGCD.?.AH ' !.;I∗45,=9/ !.;*∗45,=9> ' !.I!∗9@?. HG 45, ABJ@K ' !.!I;∗%45, K.JMFH@GA) Where: § h(t) = the expected hazard at time t § h0(t) = the baseline hazard at time t § s(t) = the expected survival probability at time t § s0(t) = the baseline survival at time t (see Table 2 for baseline survival at 12, 24, and 36 months) § Age = age in years at time of focal salvage high-dose-rate brachytherapy § ln = natural logarithm § PSA = pre-salvage prostate-specific antigen level in ng/mL § Seminal vesicle involvement = 0 when not applicable, 1 when applicable § Time to PSA nadir = post-salvage time to PSA nadir in months § %PSA reduction = PSA reduction (ratio between pre-salvage PSA and post-salvage PSA nadir) in % § PSADT = PSA-doubling time in months PSADT' can be calculated as follows: ′ = ( − 7.98 )/7 − 1.43( − 15.70)/7 + 0.44( − 33.63)/7 657.9225 8
RkJQdWJsaXNoZXIy MTk4NDMw