Thomas Willigenburg

1 General introduction and thesis outline	9
2 Evaluation of daily online contour adaptation by radiation therapists for prostate cancer treatment on an MRI-guided linear accelerator	35
3 Fast and accurate deformable contour propagation for intrafraction adaptive MRI-guided prostate radiotherapy	51
4 Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac	65
5 Clinical application of a sub-fractionation workflow for intrafraction re-planning during prostate radiotherapy treatment on a 1.5 T MR-Linac: a practical method to mitigate intrafraction motion	93
6 MRI-guided adaptive radiotherapy for prostate cancer: the first results from the MOMENTUM study, an international registry for the evidence-based introduction of MRI-guided adaptive radiotherapy	109
7 Accumulated bladder wall dose is correlated with patient-reported acute urinary toxicity in prostate cancer patients treated with stereotactic, daily adaptive MRI-guided radiotherapy	131
8 Development and internal validation of multivariable prediction models for biochemical failure after MRI-guided focal salvage high-dose-rate brachytherapy for radiorecurrent prostate cancer	157
9 Focal salvage treatment for radiorecurrent prostate cancer: an MRI-guided stereotactic body radiotherapy versus high-dose-rate brachytherapy planning study	181
10 Summary	199
11 General discussion and future perspectives	211
Nederlandse samenvatting (Summary in Dutch)	233
Publications	245
Dankwoord (Acknowledgements)	249
Curriculum vitae	255

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