Prediction models for biochemical failure after FS-HDR-BT 175 Supplementary C Supplementary D Predictor Range in dataset used for model building Pre-salvage PSADT (months) 3 – 73 months Age at FS-HDR-BT (years) 59 – 85 years Pre-salvage PSA (ng/mL) 0.4 – 39.0 ng/mL GTV (cm3) 0.5 – 22.0 cm3 Time to PSA nadir post-salvage (months) 1 – 25 months PSA reduction post-salvage (%) 0 – 100 % Figure S1 – Kaplan-Meier curve depicting biochemical disease-free survival for the entire focal salvage highdose-rate brachytherapy (FS-HDR-BT) group. Table S2 – Variables and their ranges as used for model development. Legend: PSA = Prostate-specific antigen. PSADT = PSA-doubling time. FS-HDR-BT = Focal salvage high-dose-rate brachytherapy. GTV = Gross Tumour Volume. 8
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