89 / 242
89
MIDAZOLAM/FENTANYL, PROPOFOL/ALFENTANIL OR ALFENTANIL ONLY FOR COLONOSCOPY
7
Table 1.
Patient demographics
Patient demographics Midazolam/fentanyl
Alfentanil
Propofol/alfentanil
Gender (male/female)
30/30
32/28
25/35
ASA
I
16 (27%)
17 (28%)
19 (32%)
II
35 (59%)
30 (50%)
29 (48%)
III
9 (15%)
13 (22%)
12 (20%)
Age
18-70 y
11 (18%)
9 (15%)
8 (13%)
>70 y
6 (10%)
6 (10%)
10 (17%)
Height (cm)
173+9
172+13
172+11
Weight (kg)
77+16
84+22
79+15
BMI (kg/m
2
)
26+5
27+5
27+6
Smoker
Never
46 (77%)
49 (82%)
49 (82%)
< 5/day
3 (5%)
5 (8%)
1 (2%)
>5/day
11 (18%)
6 (10%
10 (17%)
Alcohol
Never
23(38%)
28 (47%)
32 (53%)
< 2 E/day
26 (43%)
16 (27%)
25 (42%)
>2 E/day
11 (18%)
16 (27%)
3 (5%)
Data are expressed as mean±SD (weight, BMI, and height) of all patients in each group. BMI < 18.5 = low weight,
18.5–24.9 = normal limits of weight, 25–29.9 = obesity, * p < 0.05. ASA classification according American Society
of Anesthesiologists
Patient satisfaction
Patient satisfaction with the procedure was high in all groups. Most patients were ‘‘satisfied’’
(value ‘‘2’’ PSSI). In addition, patients in group P were significantly more often satisfied
(median 1.75) with the entire procedure than patients in group M (median 2.25, p<0.001)
and A (median 2.25, p<0.001; Figure 1a).
Regarding ‘‘overall negative side effects’’, no differences between groups were seen.
However, when the item ‘‘side effects’’ was subdivided in amore detailedmanner, significant
differences between the groups became obvious (Table 2). Patients in group P complained
significantly less about nausea (p<0.007) than patients in group M.
Trieger test was not significant different between the three groups (mean+SD)(midazolam
2±4.7, alfentanil 1±2.6, and propofol 2±3.6). Nevertheless, patients receiving only alfentanil
felt less drowsy, sleepy, and groggy after the procedure and scored significantly better at
‘‘lengthoftime,youfelttheeffectsofsedation’’(p<0.04)and ‘‘ability,tothinkclearly’’compared