170 Chapter 5 Supplementary table 20: Classification of 203 OSCC according to MET protein status based on agreement/differences between staining patterns observed using D1C2 and A2H2-3 using parallel WTSs. Description # % CANCERS NEGATIVE FOR THE MET RECEPTOR < 10% fraction of cancer cells show positivity for D1C2 and A2H2-3 18 8.87 CANCERS SHOWING THE MET DECOY RECEPTOR ≥ 10% fraction of cancer cells show the decoy receptor in the gradient towards periphery fraction 16 7.88 ≥ 10% fraction of cancer cells show the decoy receptor in the uniform positive fraction 3 1.48 ≥ 10% fraction of cancer cells show the decoy receptor in the gradient towards periphery & uniform positive fraction 5 2.46 ≥ 10% fraction of cancer cells show the decoy receptor in the gradient towards periphery fraction & exchange between the D1C2 and A2H2-3 positive fractions 6 2.96 ≥ 10% fraction of cancer cells show the decoy receptor in the uniform positive fraction & exchange between the D1C2 and A2H2-3 positive fractions 3 1.48 CANCERS POSITIVE FOR TM C-TERMINAL MET NOT SUBJECTIVE TO ECD SHEDDING > 90% fraction of cancer cells show the gradient towards periphery staining pattern for both D1C2 and A2H2-3 6 2.96 > 90% fraction of cancer cells show the uniform positive staining pattern for both D1C2 and A2H2-3 1 0.49 Identical scores for uniform negative, gradient towards periphery and uniform positive staining pattern for both D1C2 and A2H2-3 4 1.97 ≤ 10% difference between the sum of gradient towards periphery and uniform positive staining patterns for D1C2 and A2H2-3 19 9.36 CANCERS POSITIVE FOR TM C-TERMINAL MET SUBJECTIVE TO ECD SHEDDING ≥ 10% fraction of cancer cells show ECD shedding, which occurs in both the gradient towards periphery and uniform positive staining pattern 51 25.1 ≥ 10% fraction of cancer cells show ECD shedding, which occurs in the gradient towards periphery staining pattern 36 17.7 ≥ 10% fraction of cancer cells show ECD shedding, which occurs in the uniform positive staining pattern 16 7.88 ≥ 10% fraction of cancer cells show ECD shedding, which occurs in the center towards periphery staining pattern & exchange between D1C2 and A2H2-3 positive fractions 7 3.45 ≥ 10% fraction of cancer cells show ECD shedding, which occurs in the uniform positive staining pattern & exchange between D1C2 and A2H2-3 positive fractions 12 5.91

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