Martine De Herdt

Chapter 1 General introduction	7
Chapter 2 Context, background, aims, and outline of the thesis	27
Chapter 3 Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma	39
Chapter 4 MET ectodomain shedding is associated with poor disease-free survival of patients diagnosed with oral squamous cell carcinoma	83
Chapter 5 A novel immunohistochemical scoring system reveals associations of C-terminal MET, ectodomain shedding, and loss of E-cadherin with poor prognosis in oral squamous cell carcinoma	139
Chapter 6 The potential of MET immunoreactivity for prediction of lymph node metastasis in early oral tongue squamous cell carcinoma	187
Chapter 7 The occurrence of MET ectodomain shedding in oral cancer and its potential impact on the use of targeted therapies	209
Chapter 8 General discussion, conclusion, and future perspective	229
Chapter 9 Summary	251
Chapter 10 Samenvatting	259
Addendum List of used abbreviations, gene symbols, and terms	271
PhD portfolio	274
List of publications	277
Acknowledgements	280
Curriculum vitae	283

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