Martine De Herdt

169 MET, ECD shedding, and loss of E-cadherin Supplementary table 18: Pairwise comparison showing whether there are significant differences between the distributions of the values of the inverse staining patterns of D1C2 and NCH-38 (n=203) according to the Mann-Whitney U Test*. NCH-38 Uniform positive Uniform negative Gradient towards center D1C2 Uniform negative 0.018 N/A N/A Uniform positive N/A 0.472 N/A Gradient towards periphery N/A N/A 0.013 * Statistical significance was set at P<0.05. Supplementary table 19: Pairwise comparison showing whether there are significant differences between the distributions of the values of the corresponding D1C2 and A2H2-3 staining patterns (n=203) according to the Mann-Whitney U Test*. A2H2-3 Uniform negative Uniform positive Gradient towards periphery D1C2 Uniform negative <0.000 N/A N/A Uniform positive N/A <0.000 N/A Gradient towards periphery N/A N/A 0.005 * Statistical significance was set at P<0.05. 5

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