Accumulated bladder wall dose and urinary toxicity 141 Parameter Corrected OR* 95% CI p-value Bladder V10Gy (cm3) 1.01 0.99-1.02 0.46 V15Gy (cm3) 1.01 0.99-1.03 0.43 V20Gy (cm3) 1.01 0.98-1.04 0.43 V25Gy (cm3) 1.02 0.98-1.06 0.42 V30Gy (cm3) 1.02 0.97-1.08 0.41 V35Gy (cm3) 1.05 0.95-1.16 0.36 V37Gy (cm3) 1.05 0.89-1.25 0.57 V10Gy (%) 1.04 1.02-1.07 0.002 V15Gy (%) 1.05 1.02-1.08 0.004 V20Gy (%) 1.06 1.02-1.11 0.007 V25Gy (%) 1.08 1.02-1.15 0.009 V30Gy (%) 1.12 1.02-1.21 0.012 V35Gy (%) 1.19 1.02-1.39 0.025 V37Gy (%) 1.14 0.88-1.47 0.33 Dmean 1.20 1.07-1.35 0.002 D1cm3 1.67 0.87-3.20 0.12 D5cm3 1.34 0.99-1.81 0.06 Bladder wall V10Gy (cm3) 1.11 1.03-1.20 0.008 V15Gy (cm3) 1.14 1.03-1.25 0.011 V20Gy (cm3) 1.17 1.03-1.32 0.013 V25Gy (cm3) 1.21 1.04-1.41 0.013 V30Gy (cm3) 1.25 1.04-1.50 0.015 V35Gy (cm3) 1.30 1.03-1.64 0.027 V37Gy (cm3) 1.15 0.89-1.47 0.29 V10Gy (%) 1.06 1.02-1.10 0.003 V15Gy (%) 1.08 1.02-1.13 0.004 V20Gy (%) 1.09 1.03-1.16 0.005 V25Gy (%) 1.11 1.03-1.19 0.005 V30Gy (%) 1.12 1.03-1.22 0.008 V35Gy (%) 1.11 1.01-1.22 0.028 V37Gy (%) 1.05 0.95-1.16 0.31 Dmean 1.29 1.10-1.51 0.001 D1cm3 1.72 0.90-3.31 0.10 D5cm3 1.10 0.98-1.25 0.11 Table 3 – Corrected* odds ratios (OR) in multivariable logistic regression analysis for the outcome IPSS+10 and/or start of alpha-blockers within 3 months post-treatment. Significant values (p < 0.05) are indicated in bold. *Corrected for: age (years), diabetes (yes/no), cardiovascular disease (yes/no), baseline IPSS, and alpha-blocker usage at baseline (yes/no). Legend: IPSS = International Prostate Symptom Score. VXXGy = Absolute (cm3) and relative (%) volume receiving XX Gy. Dmean = Mean dose in Gy. DXcm3 = Dose (Gy) to the X cm3 receiving the highest dose. 7
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