Part I | Chapter 7 140 Parameter Odds ratio 95% CI OR p-value AUC 95% CI AUC Bladder V10Gy (cm3) 1.01 0.99-1.02 0.29 0.59 0.49-0.70 V15Gy (cm3) 1.01 0.99-1.03 0.28 0.58 0.48-0.69 V20Gy (cm3) 1.01 0.99-1.04 0.29 0.59 0.49-0.69 V25Gy (cm3) 1.02 0.98-1.05 0.29 0.59 0.49-0.69 V30Gy (cm3) 1.03 0.98-1.08 0.28 0.60 0.50-0.70 V35Gy (cm3) 1.05 0.96-1.16 0.27 0.60 0.50-0.70 V37Gy (cm3) 1.05 0.89-1.23 0.55 0.57 0.47-0.68 V10Gy (%) 1.04 1.02-1.07 0.002 0.67 0.58-0.77 V15Gy (%) 1.05 1.01-1.08 0.004 0.66 0.57-0.76 V20Gy (%) 1.06 1.02-1.10 0.007 0.66 0.56-0.75 V25Gy (%) 1.08 1.02-1.13 0.008 0.66 0.56-0.75 V30Gy (%) 1.11 1.02-1.12 0.011 0.66 0.56-0.75 V35Gy (%) 1.18 1.02-1.37 0.024 0.66 0.56-0.75 V37Gy (%) 1.13 0.88-1.45 0.33 0.59 0.49-0.69 Dmean 1.19 1.07-1.33 0.002 0.67 0.58-0.76 D1cm3 1.68 0.91-3.09 0.095 0.58 0.48-0.68 D5cm3 1.33 1.01-1.74 0.044 0.61 0.51-0.71 Bladder wall V10Gy (cm3) 1.10 1.03-1.18 0.006 0.65 0.54-0.75 V15Gy (cm3) 1.13 1.04-1.24 0.006 0.64 0.54-0.75 V20Gy (cm3) 1.16 1.04-1.30 0.007 0.64 0.54-0.75 V25Gy (cm3) 1.20 1.05-1.37 0.006 0.65 0.55-0.76 V30Gy (cm3) 1.24 1.06-1.46 0.007 0.65 0.55-0.75 V35Gy (cm3) 1.29 1.05-1.59 0.016 0.64 0.54-0.74 V37Gy (cm3) 1.45 0.90-1.45 0.26 0.58 0.48-0.68 V10Gy (%) 1.06 1.02-1.10 0.002 0.69 0.60-0.78 V15Gy (%) 1.07 1.02-1.13 0.003 0.67 0.58-0.77 V20Gy (%) 1.09 1.03-1.16 0.003 0.68 0.58-0.77 V25Gy (%) 1.11 1.04-1.19 0.003 0.68 0.58-0.77 V30Gy (%) 1.12 1.04-1.21 0.004 0.67 0.57-0.76 V35Gy (%) 1.12 1.02-1.22 0.016 0.65 0.55-0.75 V37Gy (%) 1.06 0.96-1.16 0.26 0.58 0.48-0.68 Dmean 1.28 1.10-1.48 0.001 0.69 0.60-0.78 D1cm3 1.75 0.95-3.21 0.071 0.59 0.49-0.70 D5cm3 1.11 1.00-1.24 0.058 0.62 0.52-0.73 Table 2 – Univariable logistic regression analysis (odds ratios [OR]) with 95% confidence intervals (CI) and area under the receiver operating characteristic (ROC) curve (AUC)) for the outcome IPSS+10 and/or start of alphablockers within 3 months post-treatment. Significant values (p < 0.05) are indicated in bold. Legend: IPSS = International Prostate Symptom Score. VXXGy = Absolute (cm3) and relative (%) volume receiving XX Gy. Dmean = Mean dose in Gy. DXcm3 = Dose (Gy) to the X cm3 receiving the highest dose.
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