MRI-guided radiotherapy for prostate cancer: the MOMENTUM study 125 BL vs. 12M p-value (ES) 0.019 (0.41) NA 0.003 (0.56) 0.406 (0.15) 0.015 (0.49) 0.009 (0.23) 0.052 (0.29) 0.142 (0.11) 0.412 (0.10) 0.007 (0.27) 0.080 (0.17) 0.351 (0.11) 12 months Median (IQR) 12.4 (8.3-16.6) 0.0 (0.0-16.5) 0.0 (0.0-10.3) 33.0 (33.0-50.0) 75.0 (58.3-83.4) 83.3 (66.7-91.7) 100.0 (86.7-100.0) 100.0 (100.0-100.0) 100.0 (100.0-100.0) 0.0 (0.0-22.2) 0.0 (0.0-16.7) 0.0 (0.0-0.0) n 42 3 40 45 38 91 91 91 91 91 91 91 BL vs. 6M p-value (ES) 0.097 (0.24) NA 0.460 (0.12) 0.557 (0.11) 0.120 (0.25) 0.002 (0.23) < 0.001 (0.27) 0.116 (0.15) 0.995 (0.03) < 0.001 (0.33) 0.153 (0.13) < 0.001 (0.27) 6 months Median (IQR) 12.4 (8.3-19.6) 0.0 (0.0-0.0) 0.0 (0.0-8.3) 33.0 (16.5-50.0) 67.0 (66.5-83.5) 83.3 (75.0-91.7) 100.0 (86.7-100.0) 100.0 (83.3-100.0) 100.0 (100.0-100.0) 11.1 (0.0-33.3) 0.0 (0.0-16.7) 0.0 (0.0-0.0) n 70 9 75 78 51 173 173 173 173 173 173 173 BL vs. 3M p-value (ES) 0.027 (0.26) NA 0.135 (0.22) 0.888 (0.02) 0.002 (0.53) < 0.001 (0.21) < 0.001 (0.23) 0.012 (0.21) 0.388 (<0.01) < 0.001 (0.22) 0.400 (0.02) 0.049 (0.15) 3 months Median (IQR) 12.4 (6.2-24.8) 0.0 (0.0-0.0) 0.0 (0.0-8.3) 33.0 (16.5-50.0) 75.3 (58.5-83.5) 83.3 (75.0-91.7) 100.0 (86.7-100.0) 100.0 (83.3-100.0) 100.0 (100.0-100.0) 11.1 (0.0-33.3) 0.0 (0.0-0.0) 0.0 (0.0-0.0) n 91 15 94 96 61 207 208 208 207 208 208 207 Baseline Median (IQR) 8.3 (4.1-16.5) 0.0 (0.0-0.0) 0.0 (0.0-0.0) 33.0 (16.5-50.0) 83.5 (64.7-91.8) 83.3 (75.0-91.7) 100.0 (93.3-100.0) 100.0 (100.0-100.0) 100.0 (100.0-100.0) 11.0 (0.0-22.2) 0.0 (0.0-0.0) 0.0 (0.0-0.0) n 128 12 129 134 80 259 259 259 259 259 259 259 QLQ-PR25 Urinary symptoms Incontinence aid (conditional) Bowel symptoms Sexual activity Sexual functioning (conditional) QLQ-C30 Global quality of life Physical functioning Role functioning Social functioning Fatigue Pain Diarrhoea Table S4 – QLQ-PR25 and QLQ-C30 outcome scores for the non-ADT group. Legend: ADT = Androgen deprivation therapy. BL = Baseline. 3M = 3 months follow-up. 6M = 6 months follow-up. 12M = 12 months follow-up. IQR = Interquartile range. ES = Effect size. NA = Not available. 6
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