Part I | Chapter 6 124 Supplementary C BL vs. 12M p-value (ES) 0.001(0.43) NA < 0.001(0.48) < 0.001(0.47) 0.204 (0.16) 0.006 (0.51) 0.004 (0.22) 0.050 (0.23) 0.072 (0.10) 0.561 (0.07) 0.025 (0.20) 0.042 (0.16) 0.336 (0.08) 12 months Median (IQR) 12.4 (8.3-20.8) 0.0 (0.0-33.0) 0.0 (0.0-8.3) 5.5 (0.0-11.2) 33.0 (16.5-33.1) 66.8 (50.0-83.5) 83.3 (66.7-91.7) 100.0 (86.7-100.0) 100.0 (87.5-100.0) 100.0 (100.0-100.0) 0.0 (0.0-22.2) 0.0 (0.0-16.7) 0.0 (0.0-0.0) n 66 5 65 66 72 48 122 122 122 122 122 122 122 BL vs. 6M p-value (ES) 0.018 (0.28) 0.999 (0.50) 0.093 (0.21) < 0.001 (0.43) 0.100 (0.14) 0.006 (0.40) < 0.001 (0.22) < 0.001 (0.30) 0.011 (0.18) 0.969 (< 0.01) < 0.001 (0.32) 0.048 (0.12) 0.001 (0.22) 6 months Median (IQR) 12.4 (8.3-20.8) 0.0 (0.0-8.3) 0.0 (0.0-8.3) 5.5 (0.0-16.5) 33.0 (0.0-33.0) 66.8 (58.3-83.5) 83.3 (75.0-91.7) 100.0 (86.7-100.0) 100.0 (83.3-100.0) 100.0 (100.0-100.0) 11.1 (0.0-33.3) 0.0 (0.0-16.7) 0.0 (0.0-0.0) n 107 16 111 106 118 62 220 220 220 220 220 220 219 BL vs. 3M p-value (ES) 0.005 (0.28) 0.999 (0.33) 0.017 (0.28) < 0.001 (0.39) 0.068 (0.16) < 0.001 (0.50) 0.005(0.16) < 0.001 (0.24) 0.003 (0.21) 0.503 (0.01) < 0.001 (0.24) 0.429 (0.02) 0.022 (0.16) 3 months Median (IQR) 12.4 (8.3-24.8) 0.0 (0.0-8.3) 0.0 (0.0-8.3) 5.5 (0.0-11.2) 33.0 (0.0-33.0) 75.0 (58.3-83.5) 83.3 (75.0-91.7) 100.0-86.7-100.0) 100.0 (83.3-100.0) 100.0 (100.0-100.0) 11.1 (0.0-33.0) 0.0 (0.0-0.0) 0.0 (0.0-0.0) n 129 20 132 126 136 72 254 255 255 254 255 255 254 Baseline Median (IQR) 8.3 (4.1-16.6) 0.0 (0.0-0.0) 0.0 (0.0-0.0) 0.0 (0.0-5.5) 33.0 (16.5-50.0) 83.5 (66.6-91.8) 83.3 (75.0-91.7) 100.0 (93.3-100.0) 100.0 (100.0-100.0) 100.0 (100.0-100.0) 11.1 (0.0-22.2) 0.0 (0.0-0.0) 0.0 (0.0-0.0) n 169 18 170 162 176 103 309 309 309 309 309 309 309 QLQ-PR25 Urinary symptoms Incontinence aid (conditional) Bowel symptoms Hormonal treatment related symptoms Sexual activity Sexual functioning (conditional) QLQ-C30 Global quality of life Physical functioning Role functioning Social functioning Fatigue Pain Diarrhoea Legend: BL = Baseline. 3M = 3 months follow-up. 6M = 6 months follow-up. 12M = 12 months follow-up. IQR = Interquartile range. ES = Effect size. NA = Not available. Table S3 – QLQ-PR25 and QLQ-C30 outcome scores for the total group.
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