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109

DEXMEDETOMIDINE. A SUMMARY

8

comparison to propofol.

13

There is not sufficient experience in the paediatric population to

ensure safety and efficacy, but dexmedetomidine appears to have a similar pharmacological

profile in children as in adults. Currently, only one dexmedetomidine solution for intravenous

usage is available, but the future could be nasal or buccal administration.

A further look into the future could be the introduction of an α

2

-antagonist in daily practice.

Atipamezole

14

is a selective α

2

-antagonist with a half-life of about 2 hours. It has been

used in veterinary medicine already for a long time to antagonise the central effects of

dexmedetomidine, but is still in phase 1 trials in humans.