Maarten Cozijnsen

Chapter 1 General introduction	9
Chapter 2 Development and validation of the mucosal inflammation non-invasive index for pediatric Crohn’s disease	33
Chapter 3 Top-down Infliximab Study in Kids with Crohn’s disease (TISKids): an international multicenter randomized controlled trial	53
Chapter 4 Infliximab has more impact than prednisolone on leukocyte RNA expression and serum inflammatory protein concentrations in peripheral blood of therapy naïve pediatric Crohn's disease patients	69
Chapter 5 Adalimumab therapy in children with Crohn’s disease previously treated with infliximab	95
Chapter 6 The benefits and risks of combining anti-tumor necrosis factor with immunomodulator therapy in pediatric inflammatory bowel disease	113
Chapter 7 General discussion	139
Summary	155
Samenvatting	159
Co-authors’ affiliations	165
About the author	169
Dankwoord	175

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