244 chapter 2 Table 57. Estimated pooled test performance of qualitative elastosonography in indeterminate thyroid nodules with alternative cutoff: elasticity score 1 (benign) versus >1 (suspicious) ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Rago 2010 142 39 103 142 (100%) 30 9 1 102 22% 97 (83-100) 92 (85-96) 11.94 (6.36-22.4) 0.04 (0.01-0.24) Lippolis 2011 102 101 1 102 (100%) 35 66 1 0 35% 97 (85-100) 0 (0-5) 0.97 (0.90-1.04) 5.43 (0.23-130) Ünlütürk 2012 18 12 6 18 (100%) 7 5 2 4 50% 78 (40-97) 44 (14-79) 1.40 (0.71-2.77) 0.50 (0.12-2.08) Cakir 2014 (1) 270 260 10 270 (100%) 81 179 0 10 30% 100 (96-100) 5 (3-10) 1.05 (1.01-1.09) 0.11 (0.01-1.86) Abdelrahman 2015 73 58 15 73 (100%) 16 42 0 15 22% 100 (79-100) 26 (16-40) 1.32 (1.11-1.58) 0.11 (0.01-1.75) Garino 2015 108 101 7 108 (100%) 33 68 0 7 31% 100 (89-100) 9 (4-18) 1.09 (1.00-1.19) 0.15 (0.01-2.54) POOLED RESULTS 713 513 127 0 713 (100%) 202 369 4 138 28.9% 98.5 (91.4- 99.8) 17.6 (2.7-61.6) 1.20 (0.84-1.70) 0.08 (0.01-0.73) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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