243 Diagnostic utility of molecular and imaging biomarkers 2 Table 56. Estimated pooled test performance of qualitative elastosonography in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Rago 2010 142 39 103 142 (100%) 30 9 1 102 22% 97 (83-100) 92 (85-96) 11.94 (6.36-22.4) 0.04 (0.01-0.24) Lippolis 2011 102 94 8 102 (100%) 32 62 4 4 35% 89 (74-97) 6 (2-15) 0.95 (0.83-1.08) 1.83 (0.49-6.90) Ragazzoni 2012 24 11 13 24 (100%) 5 6 2 11 29% 71 (29-96) 65 (38-86) 2.02 (0.91-4.49) 0.44 (0.13-1.50) Trimboli 2012 42 20 22 42 (100%) 12 8 4 18 38% 75 (48-93) 69 (48-86) 2.44 (1.28-4.63) 0.36 (0.15-0.88) Ünlütürk 2012 18 8 10 18 (100%) 6 2 3 7 50% 67 (30-93) 78 (40-97) 3.00 (0.81-11.1) 0.43 (0.16-1.15) Mohey 2013 16 3 13 16 (100%) 3 0 1 12 25% 75 (19-99) 100 (74-100) 18.2 (1.13-293) 0.31 (0.08-1.20) Cakir 2014 (1) 270 97 173 270 (100%) 58 39 23 150 30% 72 (60-81) 79 (73-85) 3.47 (2.54-4.74) 0.36 (0.25-0.51) Abdelrahman 2015 (1) 73 15 58 73 (100%) 15 0 1 57 22% 94 (70-100) 100 (94-100) 106 (6.67-1,677) 0.09 (0.02-0.41) Garino 2015 108 34 74 108 (100%) 25 9 8 66 31% 76 (58-89) 88 (78-94) 6.31 (3.32-12.0) 0.28 (0.15-0.51) Piccardo 2016 70 35 35 70 (100%) 7 28 8 27 21% 47 (21-73) 49 (35-63) 0.92 (0.50-1.67) 1.09 (0.63-1.87) POOLED RESULTS 865 356 509 0 865 (100%) 193 163 55 454 28.7% 80.0 (68.5-88.0) 81.2 (52.9-94.4) 4.27 (1.37-13.3) 0.25 (0.14-0.45) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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