The effect of SARS-CoV-2 vaccination on post-acute COVID-19 syndrome (PASC): A prospective cohort study 8 259 Total Exposure group p-value Unvaccinated Vaccinated Cough 19 (43%) 10 (45%) 9 (41%) 0.76 Myalgia 13 (26%) 6 (25%) 7 (27%) 0.88 Loss of smell/taste 18 (46%) 7 (44%) 11 (48%) 0.80 Rhinorrhoea 11 (41%) 4 (33%) 7 (47%) 0.48 Diarrhoea 9 (18%) 4 (17%) 5 (20%) 0.76 Loss of appetite 10 (24%) 1 (6%) 9 (38%) 0.020 Sore throat 4 (14%) 2 (15%) 2 (13%) 0.82 Nausea 6 (13%) 1 (5%) 5 (20%) 0.11 Fever 48 (73%) 23 (74%) 25 (71%) 0.80 Abdnominal pain 8 (27%) 6 (40%) 2 (13%) 0.099 Skin rash 2 (14%) 2 (29%) 0 (0%) 0.13 Arthralgia 10 (42%) 5 (42%) 5 (42%) 1.00 Wheeze 6 (27%) 2 (18%) 4 (36%) 0.34 Confusion 7 (35%) 4 (36%) 3 (33%) 0.89 Chest pain 7 (22%) 4 (27%) 3 (18%) 0.54 * Total number of unvaccinated matched time intervals = 36 (4 participants contributed two unvaccinated follow-up periods). †For unvaccinated participants contributing more than one follow-up period (n=4), symptoms reported at earliest matched time-point reported in this table. BMI=Body mass index; NA = Not applicable; PASC= Post-acute sequelae of COVID-19. Continuous variables presented as median (IQR) and compared using the Kruskal-Wallis test; categorical and binary variables presented as n (%) and compared using the Pearson χ2 test (or Fisher exact test if n<5). BMI categories defined as: <25 kg/m2 normal or underweight; 25-29 kg/m2 overweight; ≥30 kg/m2 obese. High-risk COVID-19 comorbidities are defined as listed by the WHO Clinical Management Guidelines and include: cardiovascular disease (including hypertension), chronic pulmonary disease (excluding asthma), renal disease, liver disease, cancer, immunosuppression (excluding HIV, including previous organ transplantation), previous psychiatric illness and dementia. Clinical severity groups defined as: mild as having a RR<20/min and SpO2 (on room air) >94% at both day 0 (D0) and day 7 (D7) study visits; moderate disease as having a RR 20-30/min, SpO2 90-94% and/or receiving oxygen therapy at D0 or D7; severe disease as having a RR>30/min or SpO2 <90% at D0 or D7; critical disease as requiring ICU admission.
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