Anouk Donners

Chapter 1 General introduction 12
Chapter 2 Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial 24
Chapter 3 Quantification of coagulation factor VIII in human plasma with liquid chromatography tandem 50
Chapter 4 Comparison between coagulation factor VIII quantified with one-stage activity assay and with mass spectrometry in haemophilia A patients: Proof of principle 68
Chapter 5 Quantification of emicizumab by mass spectrometry in plasma of people with haemophilia A: A method validation study 84
Chapter 6 Pharmacokinetics and Associated Efficacy of Emicizumab in humans: A Systmatic Review 102
Chapter 7 The efficacy of the entire-vial dosing of emicizumab: real-world evidence on plasma concentrations, bleeds and drug waste 124
Chapter 8 DosEmi study protocol: a phase IV, multicenter, open-label, crossover study to evaluate noninferiority of pharmacokinetic-guided reduced dosing compared with conventional dosing of emicizumab in persons with haemophilia A 142
Chapter 9 General Discussion 158
Chapter 10 Summary 180
Chapter 11 Nederlandse lekensamenvatting 186
About the author 194
List of coauthors 195
List of publications 198
Dankwoord 200