Anouk Donners

Chapter 1 General introduction	12
Chapter 2 Six-step workflow for the quantification of therapeutic monoclonal antibodies in biological matrices with liquid chromatography mass spectrometry - A tutorial	24
Chapter 3 Quantification of coagulation factor VIII in human plasma with liquid chromatography tandem	50
Chapter 4 Comparison between coagulation factor VIII quantified with one-stage activity assay and with mass spectrometry in haemophilia A patients: Proof of principle	68
Chapter 5 Quantification of emicizumab by mass spectrometry in plasma of people with haemophilia A: A method validation study	84
Chapter 6 Pharmacokinetics and Associated Efficacy of Emicizumab in humans: A Systmatic Review	102
Chapter 7 The efficacy of the entire-vial dosing of emicizumab: real-world evidence on plasma concentrations, bleeds and drug waste	124
Chapter 8 DosEmi study protocol: a phase IV, multicenter, open-label, crossover study to evaluate noninferiority of pharmacokinetic-guided reduced dosing compared with conventional dosing of emicizumab in persons with haemophilia A	142
Chapter 9 General Discussion	158
Chapter 10 Summary	180
Chapter 11 Nederlandse lekensamenvatting	186
About the author	194
List of coauthors	195
List of publications	198
Dankwoord	200

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