72 Chapter 3 Supplementary table S5: The effect of baseline characteristics on 5-year OS and DFS. Explanatory variable No. of patients 5-year OS 5-year DFS # % HR 95% CI p-value HR 95% CI p-value Sex Male 114 63.69 Female 65 36.31 1.181 0.781 – 1.787 0.431 1.249 0.841 – 1.857 0.271 Age at diagnosis (years) Mean (range) 62.97 (34 – 87) 1.017 0.998 – 1.035 0.075 1.019 1.001 – 1.037 0.039 Smoking No 60 33.52 Yes 117 65.36 1.289 0.823 – 2.019 0.268 1.200 0.785 – 1.833 0.400 Missing 2 1.12 Alcohol No 81 45.25 Yes 96 53.63 0.978 0.649 – 1.475 0.917 0.859 0.580 – 1.272 0.449 Missing 2 1.12 Site Oral cavity 157 87.71 Oropharynx 22 12.29 0.865 0.461 – 1.623 0.653 0.882 0.483 – 1.611 0.682 cT-stage cT1-2 95 53.07 cT3-4 84 46.93 2.005 1.329 – 3.027 0.001 1.776 1.200 – 2.629 0.004 cN-stage cN0 113 63.13 cN1-3 66 36.87 2.998 1.991 – 4.514 < 0.001 2.520 1.702 – 3.729 < 0.001 pT-stage pT1-2 91 50.84 pT3-4 88 49.16 2.218 1.457 – 3.377 < 0.001 1.909 1.283 – 2.841 0.001 pN-stage pN0 75 41.90 pN1-3 104 58.10 2.035 1.318 – 3.144 0.001 1.867 1.239 – 2.814 0.003 Infiltration depth < 4.0 mm 9 5.03 ≥ 4.0 mm 170 94.97 1.778 0.563 – 5.616 0.327 2.087 0.662 – 6.584 0.209 Differentiation grade Good – moderate 141 78.77 Poor 38 21.23 1.743 1.102 – 2.756 0.017 1.541 0.981 – 2.421 0.061
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