185 MET, ECD shedding, and loss of E-cadherin Supplementary figure 11: ROC curves used to determine the cut off ≥10% of cancer cells showing MET ECD shedding within the D1C2 uniform positive staining pattern in view of survival analyses for DFS for cancers positive for TM C-terminal MET positive cancers in the gradient towards periphery and/ or uniform positive staining pattern (n=152). A. ROC curve used to determine the maximal value of the Youden index – indicated with the dashed line – to determine the optimal cut-off for % of cancer cells showing MET ECD shedding within the D1C2 uniform positive staining pattern in view of survival analyses (P=0.011). B. Results ROC curve obtained using the optimal cut off of 6.25% of cancer cells showing MET ECD shedding within the D1C2 uniform positive staining pattern (P=0.007). 5
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