172 Chapter 5 Supplementary table 21: (Continued) Explanatory variable No. of patients OS DFS # % HR 95% CI P-value HR 95% CI P-value pN category dichotomous pN0 OR pN1 119 78.3 ≥ pN2 32 21.1 2.91 1.71 – 4.94 0.000 1.92 1.16 – 3.17 0.011 Missing 1 0.66 Cancer stage**, *** I 48 31.6 0.020 0.51 II 24 15.8 1.60 0.70 – 3.65 0.26 1.17 0.59 – 2.33 0.65 III 26 17.1 1.37 0.59 – 3.20 0.47 1.01 0.50 – 2.04 0.98 IV 48 31.6 2.74 1.41 – 5.34 0.003 1.49 0.85 – 2.62 0.17 Missing 6 3.95 Extranodal extension**** Absent OR pN0 128 84.2 Yes 21 13.8 1.95 1.03 – 3.68 0.039 1.37 0.74 – 2.54 0.32 Missing 3 1.97 Degree of differentiation dichotomous Well – moderate 115 75.7 Poor - undifferentiated 19 12.5 1.59 0.80 – 3.17 0.19 1.20 0.63 – 2.29 0.58 Missing 18 11.8 Growth pattern Cohesive 95 62.5 Non-cohesive 56 36.8 1.15 0.69 – 1.93 0.59 1.14 0.72 – 1.81 0.57 Missing 1 0.66
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