164 Chapter 5 Supplementary table 5: Results of performed ROC curve analyses in view of determining the cut off for percentage of cancer cells showing the uniform positive staining pattern for D1C2 in view of survival analyses for OS for patients showing overall more C- than N-terminal MET immunoreactivity using Youden’s J statistic (n=152). Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound Results ROC curve used to determine the maximal value of the Youden index to determine the optimal cut-off for % of cancer cells showing the uniform positive staining pattern for D1C2 in view of survival analyses 0.62 0.046 0.012 0.53 0.71 Results ROC curve obtained using the optimal cut off of 6.25 cancer cells showing the uniform positive staining pattern for D1C2 0.62 0.045 0.013 0.53 0.71 Supplementary table 6: Sensitivity, specificity, positive predictive and negative predictive value, accuracy and AUC of D1C2 uniform positive staining pattern in view of survival analyses with respect to OS for patients showing overall more C- than N-terminal MET immunoreactivity (n=152). Positive test result was set at ≥ 6.25% D1C2 uniform positivity Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%) AUC (95% CI) Cancers showing overall more C- than N-terminal MET immunoreactivity 83.9 40.0 49.1 78.3 57.9 0.62 (0.53; 0.71) Supplementary table 7: Results of performed ROC curve analyses in view of determining the cut off for percentage of cancer cells showing the uniform positive staining pattern for D1C2 in view of survival analyses for DFS for patients showing overall more C- than N-terminal MET immunoreactivity using Youden’s J statistic (n=152). Area Std. error Asymptotic sig. Asymptotic 95% confidence interval Lower bound Upper bound Results ROC curve used to determine the maximal value of the Youden index to determine the optimal cut-off for % of cancer cells showing the uniform positive staining pattern for D1C2 in view of survival analyses 0.62 0.046 0.008 0.53 0.71 Results ROC curve obtained using the optimal cut off of 12.5 cancer cells showing the uniform positive staining pattern for D1C2 0.61 0.046 0.018 0.52 0.70
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