161 MET, ECD shedding, and loss of E-cadherin Definitions used for OS and DFS OS was defined as the time in months from the date of primary surgery to: the date of death due to any cause or the cutoff time (set at 60 months). DFS was defined as the time in months from the date of primary surgery to: the date of first evidence of any disease (local, regional, distant or secondary primary) progression, the date of death due to any cause or the cutoff time (set at 60 months). Individuals who were: lost to follow-up or survived beyond the cutoff time, were considered as censored observations. 5
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