133 MET ECD shedding and poor DFS Supplementary figure 5: Examination of the nature of N-terminal MET immunoreactivity across cancer surfaces and whether there is an association of N-terminal MET immunoreactivity and disease free survival and/or overall survival using bubble plots*. A. Bubble plot used to examine the nature of N-terminal MET immunoreactivity across cancer surfaces. The result shows that bubbles are predominantly present in the lower left corner of the chart area, meaning that overall N-terminal MET immunoreactivity is generally low across cancers. B. Bubble plot used to examine whether there is a relation between the behavior of N-terminal MET immunoreactivity across cancer surfaces and disease free survival (white bubble: disease free; blue bubble: not disease free or dead). For both survival measures there was an even distribution of events across the chart area, meaning that there is no association with both survival measures and the behavior of N-terminal MET immunoreactivity.** * The area of each bubble represents the number of cancers showing identical immunoreactivity across the cancer surface stratified to survival status in B. ** As the bubble plots representing the distribution of disease free survival and overall survival are practically identical, only the result for disease free survival was shown. 4
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