Clinical application of a sub-fractionation workflow 99 Based on the population systematic (å) and population random (s) errors of the (measured) intrafraction motion and accounting for remaining intrafraction rotation motion20, PTV margins of 1.0 mm (LR), 2.4 mm (CC), and 2.6 mm (AP) would be required according the van Herk formula (Supplementary B). Figure 2 – Average residual intrafraction Clinical Target Volume (CTV) displacement with the sub-fractionation workflow (1xATS + 2xATP) in the left-right, cranial-caudal, and anterior-posterior direction (as indicated by the dots, squares, and diamonds, respectively) for all fractions (n = 5) separately per patient. For clarity, for each patient the measurements are stratified horizontally by direction. In case there are two or more measurements (for a single patient and in the same direction) with an equal value, these are displayed slightly shifted next to each other. Negative values are in the right, caudal, and anterior direction. 5
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