TABLE OF CONTENTS 1 General introduction and thesis outline 9 PART I 2 Evaluation of daily online contour adaptation by radiation therapists for prostate cancer treatment on an MRI-guided linear accelerator 35 3 Fast and accurate deformable contour propagation for intrafraction adaptive MRI-guided prostate radiotherapy 51 4 Seminal vesicle intrafraction motion during the delivery of radiotherapy sessions on a 1.5 T MR-Linac 65 5 Clinical application of a sub-fractionation workflow for intrafraction re-planning during prostate radiotherapy treatment on a 1.5 T MR-Linac: a practical method to mitigate intrafraction motion 93 6 MRI-guided adaptive radiotherapy for prostate cancer: the first results from the MOMENTUM study, an international registry for the evidence-based introduction of MRI-guided adaptive radiotherapy 109 7 Accumulated bladder wall dose is correlated with patient-reported acute urinary toxicity in prostate cancer patients treated with stereotactic, daily adaptive MRI-guided radiotherapy 131 PART II 8 Development and internal validation of multivariable prediction models for biochemical failure after MRI-guided focal salvage high-dose-rate brachytherapy for radiorecurrent prostate cancer 157 9 Focal salvage treatment for radiorecurrent prostate cancer: an MRI-guided stereotactic body radiotherapy versus high-dose-rate brachytherapy planning study 181 PART III 10 Summary 199 11 General discussion and future perspectives 211 APPENDICES Nederlandse samenvatting (Summary in Dutch) 233 Publications 245 Dankwoord (Acknowledgements) 249 Curriculum vitae 255
RkJQdWJsaXNoZXIy MTk4NDMw