Part I | Chapter 3 52 Abstract To facilitate full intrafraction adaptive MRI-guided radiotherapy, accurate contour propagation is needed. We aimed to assess the clinical usability of intrafraction-propagated contours by a deformable image registration algorithm in ten prostate cancer patients. Two observers judged the contours on need for manual adaptation and feasibility of adapting contours within 3 min. CTV and bladder contours needed none or only minor editing in most cases (³ 97%), whereas rectum contours needed more extensive editing in 12-23%. Nevertheless, adaptation times were < 3 min for ³ 93% of the cases. This paves the way for exploring adaptive workflows using intrafraction deformable contour propagation.
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