Chapter 1 20 MOMENTUM study and Utrecht Prostate Cohort study The chapters in the first part of this thesis are based on manuscripts that use data from two prospective cohort studies. All patients, including prostate cancer patients at the UMC Utrecht, who are treated on one of the MR-Linacs at a participating centre, are asked to participate in the MOMENTUM (‘Multi-OutcoMe EvaluatioN of radiation Therapy Using the MR-Linac’) study (NCT04075305).72 The MOMENTUM study is an international, prospective registry that was established with the aim of facilitating evidence-based clinical implementation of the 1.5 T Unity MR-Linac. Within the registry, clinical and technical data is collected at baseline, during treatment, and during follow-up. Since February 2020, all patients who are diagnosed with primary localised prostate cancer at the UMC Utrecht or St. Antonius hospital (Utrecht and Nieuwegein, The Netherlands) are asked to participate in the prospective Utrecht Prostate Cohort (UPC) study (NCT04228211). Whereas the MOMENTUM study solely includes patients treated on an MR-Linac, the UPC study additionally includes patients treated with other primary treatments or who undergo an active surveillance strategy. Like the MOMENTUM study, the UPC study prospectively collects clinical patient and treatment data at baseline and during follow-up in patients with primary localised prostate cancer. Besides physician-reported outcomes, patient-reported outcomes on toxicity and quality of life are collected using multiple questionnaires. Both cohorts allow evaluation of current treatments and outcomes as well as the initiation of (randomised) trials that investigate a new treatment. Furthermore, the imaging and technical data collected in the studies can be used in many different ways, for example to study technological innovations. Figure 4 – Overview of the clinical MR-Linac workflow for prostate cancer patients. Legend: CT = Computed Tomography. MRI = Magnetic Resonance Imaging. PV = Position Verification. ATP = Adapt-to-Position.
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