Part II | Chapter 8 172 of delineation guidelines will be present and influences the accuracy and predictive value of this variable. Conclusion This study provides two models for biochemical failure prediction in patients with radiorecurrent prostate cancer treated with FS-HDR-BT. Our findings support that both pre- and post-salvage PSA characteristics (PSA level, PSADT, time to PSA nadir, and PSA reduction) are important predictors of biochemical failure, in addition to age, tumour volume, and seminal vesicle involvement. These models could aid patient selection, counselling, and guidance at baseline and during follow-up. Potentially, thesemodels can also be used for other salvage techniques, for which external validation remains necessary.
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