Thomas Willigenburg

Accumulated bladder wall dose and urinary toxicity 151 Supplementary D Figure S2 – Univariable receiver operating characteristic (ROC) curves for bladder Dmean (A), bladder wall Dmean (B), and absolute bladder wall V25Gy (C) and the binary outcome (IPSS+10 and/or start of alpha-blocking medication within 3 months post-treatment). The optimal cut-off points, as determined by the Youden index, are indicated as a black dot, together with the corresponding dose cut-off (in Gy for the Dmean and in cm3 for the absolute V25Gy) and the specificity and sensitivity within brackets. A B C 7

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