Part I | Chapter 6 116 Patient-reported outcomes For the QLQ-PR25 urinary symptoms domain score, a significant increase in median score from 8.3 (IQR: 4.1-16.6) at baseline to 12.4 (IQR: 8.3-24.8; p = 0.005; ES = 0.28) at 3 months, 12.4 (IQR: 8.3-20.8; p = 0.018; ES = 0.28) at 6 months, and 12.4 (IQR: 8.3-20.8; p = 0.001; ES = 0.43) at 12 months FU was observed (Figure 2 and Table S3-5 in Supplementary C). Median bowel symptom domain scores did not change between baseline and all FU moments. After stratifying for ADT, no change was observed in the median sexual activity domain score in the non-ADT group, but a significant decline in the median sexual functioning domain score was observed, from 83.5 (IQR: 64.7-91.8) at baseline to 75.3 (IQR: 58.5-83.5; p = 0.002; ES = 0.53) at 3 months, and 75.0 (IQR: 58.3-83.4; p = 0.015; ES = 0.49) at 12 months FU. Figure 2 – Boxplots of QLQ-PR25 domain scores at baseline and follow-up. (A) Urinary symptoms domain. (B) Bowel symptoms domain. Continues on next page.
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