Chapter 3 60 Table 2. Univariable and multivariable linear regression analyses with dIEM, iEM and plasma magnesium as dependent variable. dIEM, mmol/1012 cells iIEM, mmol/1012 cells Plasma magnesium, mmol/L Determinants Univariable St. β (95% CI) Multivariable St. β (95% CI) Univariable St. β (95% CI) Multivariable St. β (95% CI) Univariable St. β (95% CI) Multivariable St. β (95% CI) Age, years 0.15 (0.10; 0.19)** 0.11 (0.05; 0.17)** 0.13 (0.08; 0.18)** 0.11 (0.05; 0.16)** 0.08 (0.03; 0.13)* 0.03 (-0.03; 0.09) Sex, female -0.003 (-0.05; 0.05) 0.05 (-0.004; 0.10) 0.03 (-0.07; 0.13) 0.13 (0.03; 0.23)* -0.03 (-0.08; 0.02) -0.02 (-0.07; 0.04) Anthropometry Body mass index, kg/m2 0.05 (0.01; 0.10)* 0.04 (-0.01; 0.08) 0.09 (0.05; 0.14)** 0.08 (0.03; 0.13)* -0.05 (-0.10; -0.004)* -0.07 (-0.12; -0.02)* Waist circumference, cm 0.06 (0.02; 0.11)* -0.01 (-0.11; 0.09) 0.11 (0.07; 0.16)** 0.10 (-0.01; 0.20) -0.002 (-0.05; 0.05) -0.04 (-0.10; 0.01) Glucose metabolism Log10 glucose, mmol/L 0.03 (-0.02; 0.08) -0.01 (-0.07; 0.05) 0.04 (-0.01; 0.09) 0.003 (-0.05; 0.06) -0.14 (-0.19; -0.09)** -0.17 (-0.23; -0.11)** Log10 HbA1c, mmol/mol -0.001 (-0.05; 0.05) -0.07 (-0.12; -0.02)* 0.04 (-0.01; 0.08) -0.02 (-0.07; 0.04) -0.10 (-0.15; -0.05)** -0.15 (-0.20; -0.09)** Lipid metabolism Total cholesterol, mmol/L 0.12 (0.07; 0.16)** 0.07 (0.02; 0.12)* 0.12 (0.07; 0.17)** 0.08 (0.03; 0.12)* 0.12 (0.08; 0.17)** 0.11 (0.06; 0.16)** LDL cholesterol, mmol/L 0.10 (0.06; 0.15)** 0.07 (0.02; 0.12)* 0.09 (0.04; 0.14)** 0.06 (0.01; 0.11)* 0.13 (0.08; 0.18)** 0.12 (0.07; 0.16)** HDL cholesterol, mmol/L -0.02 (-0.07; 0.03) -0.05 (-0.10; 0.01) -0.03 (-0.08; 0.02) -0.06 (-0.12; -0.01)* -0.002 (-0.05; 0.05) -0.03 (-0.09; 0.03) Log10 triglycerides, mmol/L 0.11 (0.07; 0.16)** 0.10 (0.05; 0.15)** 0.15 (0.10; 0.19)** 0.14 (0.09; 0.19)** 0.05 (0.002; 0.10)* 0.06 (0.01; 0.11)* Blood pressure Systolic, mm Hg 0.04 (-0.004; 0.09) -0.01 (-0.07; 0.04) 0.07 (0.03; 0.12)* 0.01 (-0.04; 0.07) 0.01 (-0.04; 0.06) -0.001 (-0.06; 0.06) Diastolic, mm Hg 0.05 (-0.002; 0.09) 0.02 (-0.03; 0.07) 0.06 (0.01; 0.11)* 0.03 (-0.02; 0.08) 0.06 (0.01; 0.11)* 0.07 (0.01; 0.12)* Renal function eGFR < 90 ml/min/1.73m2 0.16 (0.06; 0.26)* -0.01 (-0.12; 0.11) 0.13 (0.03; 0.23)* -0.03 (-0.14; 0.09) 0.17 (0.07; 0.28)* 0.13 (0.003; 0.25)* Creatinine clearance, mL/ min -0.05 (-0.10; 0.002) -0.003 (-0.06; 0.05) -0.04 (-0.09; 0.01) -0.01 (-0.07; 0.05) -0.08 (-0.13; -0.03)* -0.05 (-0.11; 0.01) Plasma levels Sodium, mmol/L 0.15 (0.10; 0.20)** 0.13 (0.09; 0.18)** 0.14 (0.10; 0.19)** 0.13 (0.08; 0.18)** 0.14 (0.09; 0.19)** 0.13 (0.08; 0.18)** Potassium, mmol/L 0.13 (0.08; 0.18)** 0.11 (0.06; 0.16)** 0.07 (0.02; 0.12)* 0.04 (-0.01; 0.09) 0.08 (0.03; 0.13)* 0.06 (0.01; 0.11)*
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