Chapter 1 16 As alluded to above, cortisol excess may affect cardiovascular health. To gain more mechanistic insight, we investigate the effects of oral magnesium supplementation on glucocorticoid metabolism in Chapter 5, as a potential underlying mechanism by which increased dietary magnesium intake may beneficially affect cardiovascular health. To do so, we perform post-hoc analyses using data from the previous RCT on magnesium citrate supplementation that we performed in collaboration with researchers from the University of Maastricht 17. In Chapter 6, we investigate the effects of oral magnesium supplementation on arterial stiffness in an RCT of 164 healthy overweight and slightly obese Dutch adults. Our aim is two-fold: i) to replicate the effect of oral magnesium citrate supplementation on arterial stiffness that was found in the previous study 17 and ii) to examine whether other commercially available inorganic magnesium supplements, including magnesium oxide and magnesium sulfate, are non-inferior to effects of magnesium citrate supplements on arterial stiffness. We additionally assess effects on blood pressure, plasma and urinary magnesium, and gastro-intestinal tolerability.
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