135 7 AOC for very preterm infants and neurodevelopmental outcome at two years Supplementary table 2: Post-implementation Automated Oxygen Control loss to follow-up characteristics Patient characteristics Post-AOC Data available n = 261 Loss to follow-up n = 31 p value* Gestational age in weeksdays, median [IQR] 280 [261 – 285] 286 [275 – 294] 0.001 Birth weight in grams, mean (SD) 1020 (263) 1175 (193) 0.002 Males, n (%) 136 (52.1) 19 (61.3) 0.33 Antenatal corticosteroids, n (%) 225 (87.2) 28 (90.3) 0.62 Caesarean delivery, n (%) 140 (53.6) 14 (45.2) 0.37 Multiple pregnancy, n (%) 83 (31.8) 14 (45.2) 0.14 of which monochorionic twins, n (%) 50 (60.2) 12 (85.7) 0.08 Perinatal asphyxia, n (%) 8 (2.7) 0 (0.0) 1.00 Apgar score at 5 minutes, median (range) 8 (1-10) 8 (2-10) 0.36 Intraventricular haemorrhage (≥ stage 2), n (%) 45 (17.2) 4 (12.9) 0.54 Periventricular leukomalacia (≥ stage 2), n (%) 6 (2.3) 0 (0.0) 1.00 Received laser coagulation for ROP, n (%) 13 (6.0) 1 (3.3) 1.00 Bronchopulmonary dysplasia severe, n (%) 47 (20.9) 1 (3.3) 0.051 moderate, n (%) 4 (1.8) 0 (0.0) mild, n (%) 34 (15.1) 3 (10.0) AOC, Automated Oxygen Control; ROP, Retinopathy of prematurity; *Statistical analysis with independent T-test, chi-square, Fisher’s exact or nonparametric Mann-Whitney U test as appropriate

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