127 7 AOC for very preterm infants and neurodevelopmental outcome at two years Outcomes at two year follow-up Thecompositeprimaryoutcomeofmortalityor severeNDI occurred in17.9%(41/229; Table 2) before implementation of AOC versus 24.0% (47/196) after implementation (p=0.12). The majority was related to neonatal death (10.2% (30/289) vs. 10.8% (32/292) p=0.82). After the neonatal period 0.4% (1/259) vs. 0.8% (2/259; p=0.56) children died. Severe NDI was observed in 5.1% (10/198) before vs. 8.0% (13/162) after the implementation of AOC (p=0.25). Mild to moderate NDI was detected in 38.5% (82/213) infants pre-AOC vs. 43.8% (78/178) after implementation (p=0.29). Table 2. Outcomes at two years follow-up Pre-AOC Post-AOC p value* Adverse outcome (severe NDI or death) 41 (17.9) 47 (24.0) 0.12 Severe NDI, n (%) 10 (5.1) 13 (8.0) 0.25 Early death, n (%) 30 (10.2) 32 (10.8) 0.82 Late death, n (%) 1 (0.4) 2 (0.8) 1.00 Mild-moderate NDI, n (%) 82 (38.5) 78 (43.8) 0.29 BSID III Composite motor score, median [IQR] 97 [89 – 107] 98 [89 – 109] 0.18 Score 70-85, n (%) 25 (12.6) 25 (12.8) 0.94 Score <70, n (%) 5 (2.5) 11 (5.6) 0.12 BSID III Composite cognitive score, median [IQR] 96 [87 – 101] 96 [91 – 105] 0.23 Score 70-85, n (%) 31 (13.4) 26 (12.7) 0.85 Score <70, n (%) 7 (3.0) 7 (3.4) 0.81 CBCL externalising T score, mean (SD) 51 (10) 50 (10) 0.69 CBCL internalising T score, median [IQR] 47 [41 – 55] 47 [41 – 55] 0.59 Visual impairment, n (%) None 213 (90.6) 166 (86.0) 0.25 Mild impairment 19 (8.1) 25 (13.0) Limited vision 3 (1.3) 2 (1.0) Blind 0 (0) 0 (0) Hearing loss, n (%) None 229 (98.3) 185 (96.4) 0.23 Mild hearing loss 2 (0.9) 3 (1.6) Abnormal, neurosensory hearing loss 0 (0) 3 (1.6) Deaf 2 (0.9) 1 (0.5) Table 2 continues on next page
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