Tamara van Donge

Chapter 1 Introduction into quantitative clinical pharmacology and pediatrics	11
Chapter 2 Clinical pharmacology and pharmacometrics to better understand physiological changes during pregnancy and neonatal life	23
Chapter 3 Key components for antibiotic dose optimization of sepsis in neonates and infants	41
Chapter 4 Amoxicillin dosing regimens for the treatment of neonatal sepsis: balancing efficacy and neurotoxicity	59
Chapter 5 Methadone dosing strategies in preterm neonates can be simplified	75
Chapter 6 A novel strategy to personalize use of ibuprofen for closure of patent ductus arteriosus in preterm neonates	97
Chapter 7 Characterizing dynamics of serum creatinine and creatinine clearance in extremely low birth weight neonates during the first six weeks of life	125
Chapter 8 Creatinine trends to detect ibuprofen-related maturational adverse drug events in neonatal life: a simulation study for the ELBW newborn	151
Chapter 9 Age-dependent changes of kidney injury biomarkers in pediatrics	165
Chapter 10 Age appropriate reference intervals for eight serum kidney biomarkers in healthy infants, children and adolescents	193
Chapter 11 General discussion and future perspectives	229
Chapter 12 Summary	243
Affiliations of co-authors	251
PhD portfolio	257
List of publications	263
About the author	269
Acknowledgements	273

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