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TABLE OF CONTENTS

Chapter 1

Introduction and outline of the thesis

PART 1 SEDATION: YES OR NO?

Chapter 2

Transfemoral aortic valve replacement:

does anaesthesia make the difference?

British Journal of Anaesthesia 2016; 116: 14-15

Chapter 3

Towards minimally invasiveness: transcatheter aortic

valve implantation under local analgesia exclusively.

International Journal of Cardiology 2014; 176: 1050-1052

Chapter 4

Achalasia and peroral endoscopic myotomy (poem).

A & I 2016; 9: 19-25

Chapter 5

Analgesia without sedatives during colonoscopies:

worth considering?

Techniques in Coloproctology 2012; 16: 271-276

PART 2 SEDATION: YES, BUT HOW TO ACHIEVE BEST?

Chapter 6

A multi-centre randomised double-blind placebo-controlled

trial to evaluate the value of a single bolus intravenous

alfentanil in CT colonography.

BMC Gastroenterology 2013; 13: 94-103

Chapter 7

Is “really conscious” sedation with solely an opioid an alternative

to every day used sedation regimes for colonoscopies in a

teaching hospital? Midazolam/fentanyl, propofol/alfentanil,

or alfentanil only for colonoscopy: a randomised trial.

Techniques in Coloproctology 2014; 18: 745-752

Chapter 8

Dexmedetomidine – a summary.

A & I 2012; 1: 39-44