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Chapter 10

effectiveness analysis was performed. A further limitation is the lack of a direct comparison

to other sedation strategies (e.g. sedation with midazolam with or without [al]fentanyl

or general anaesthesia), since this study only investigates one specific sedation strategy,

namely sedation with propofol and remifentanil TCI. Therefore, no conclusions can be

drawn about the superiority of this sedation strategy over other sedation strategies, which

have been successfully used in earlier clinical trials. Randomised controlled trials, preferably

multicentre trials, that compare different sedation strategies are necessary to investigate

the value of the different sedation strategies.

In conclusion, BT is a rapidly emerging bronchoscopic treatment for patients with severe

asthma. Sedation with propofol and remifentanil TCI provided by specialised sedation

anaesthesia nurses is feasible and safe and results in high satisfaction scores by both,

patients and bronchoscopists.