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Chapter 10
effectiveness analysis was performed. A further limitation is the lack of a direct comparison
to other sedation strategies (e.g. sedation with midazolam with or without [al]fentanyl
or general anaesthesia), since this study only investigates one specific sedation strategy,
namely sedation with propofol and remifentanil TCI. Therefore, no conclusions can be
drawn about the superiority of this sedation strategy over other sedation strategies, which
have been successfully used in earlier clinical trials. Randomised controlled trials, preferably
multicentre trials, that compare different sedation strategies are necessary to investigate
the value of the different sedation strategies.
In conclusion, BT is a rapidly emerging bronchoscopic treatment for patients with severe
asthma. Sedation with propofol and remifentanil TCI provided by specialised sedation
anaesthesia nurses is feasible and safe and results in high satisfaction scores by both,
patients and bronchoscopists.