Maarten van Egmond

50 Chapter 3 Table 2. Reasons for loss to follow-up Reasons for loss to follow-up* T3 T4 Total patients not measured 46 (29.6) 49 (46.8) Deceased 0 (0) 5 (4.6) No show, reason unknown 0 (0) 20 (20.2) Planning reasons 4 (2.6) 0 (0) Unable to test due to complications 20 (12.9) 6 (5.5) Too weak/sick to be tested 5 (3.2) 6 (5.5) Unspecified refusal to cooperate 9 (5.8) 7 (6.4) No resectable tumor 2 (1.3) 0 (0) Psychosocial reasons 1 (0.6) 0 (0) Unspecified personal circumstances 2 (1.3) 3 (2.8) Metastasis 3 (1.9) 2 (1.8) * With percentages in parentheses. In the group of patients suffering from postoperative complications, most of the functional status measures at T4 returned to baseline levels (beta [95% CI]: 30CST (-0.4, [-10.2 to 9.3]; P = . 93), MIP (-6.7, [-15.9 to 2.4]: P = .15), ADL (-70.3, [-284.6 to 144.0]; P = .52), 2MWT (-8.8, [-18.7 to 1.1]; P = .08), HRQL (-4.7, [-10.3 to 0.9]; P = .10), but these patients had significantly less HGS (beta [95% CI]: (-9.0, [-17.3 to -0.7]; P = .03) and experienced more fatigue (7.2, [2.1 to 12.2]; P = .006). Table 3. Differences in functional status outcomes Measurements T1 T2 Δ T2-T1 (95% CI) HGS 111.0 (25.9) 114.3 (21.7) 2.6 (-1.3 to 6.5) MIP 119.7 (40.6) 125.4 (38.5) 4.1 (-0.6 to 8.7) 30CST 118.1 (28.9) 117.0 (38.2) 0.3 (-4.69 to 5.25) 2MWT (m) 193.6 (29.2) 202.3 (35.6) 9.4 (4.0 to 14.7) MFI fatigue, median (IQR) 45.5 (26.3) 40.8 (23.8) -4.7 (-7.6 to -1.7) EORTC QLQ C30 quality of life (%) median (IQR) 73.4 (15.7) 80.5 (14.2) 7.1 (3.9 to 10.3) LAPAQ (Kcal/day) median (IQR) 475.4 (550.2) 864.5 (671.0) 364.0 (177.6 to 550.3) Functional status measurements are presented as a percentage of the predicted value in means ± standard deviation (SD), unless otherwise stated. Abbreviations: MIP, maximal inspiratory pressure; HGS, handgrip strength; 30CST, 30-second chair stand test; 2MWT, 2-minute walk test; MFI, multidimensional fatigue inventory: scores range from 20 to 100 with a higher score representing more fatigue, reduced activity/ motivation;