Franny Jongbloed

TABLE OF CONTENTS PART I. INTRODUCTION Chapter 1 General introduction & aims and outline of this thesis 11 PART II. MECHANISMS OF DIETARY RESTRICTION Chapter 2 Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice PLoS One. 2014 Jun 24;9(6):e100853 23 Chapter 3 The transcriptomic response to irinotecan in fasted colon carcinoma bearing mice Submitted 51 Chapter 4 A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction Scientific Reports. 2017 Jan 19;7:40901 79 Chapter 5 The role of protein and essential amino acids in the protection against hepatic ischemia-reperfusion injury in mice Manuscript 117 PART III. CLINICAL APPLICATIONS OF DIETARY RESTRICTION Chapter 6 The effects of morbid obesity, metabolic syndrome and bariatric surgery on aging of the T-cell immune system Submitted 145 Chapter 7 Preoperative calorie and protein restriction is feasible and safe in healthy kidney donors and morbidly obese patients: a pilot study Nutrients. 2016 May 20;8(5):306 167 Chapter 8 Combined calorie and protein restriction improves outcome in living kidney donors and kidney transplant recipients Submitted 199 PART IV SUMMARY AND DISCUSSION Chapter 9 Summary and discussion 241 Chapter 10 Nederlandse samenvatting 259 APPENDICES Dankwoord 273 List of publications 279 Curriculum Vitae 281 PhD portfolio 283