Franny Jongbloed

PART I. INTRODUCTION 6
Chapter 1 General introduction & aims and outline of this thesis 8
PART II. MECHANISMS OF DIETARY RESTRICTION 21
Chapter 2 Preoperative fasting protects against renal ischemia-reperfusion injury in aged and overweight mice PLoS One. 2014 Jun 24;9(6):e100853 23
Chapter 3 The transcriptomic response to irinotecan in fasted colon carcinoma bearing mice Submitted 51
Chapter 4 A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction Scientific Reports. 2017 Jan 19;7:40901 79
Chapter 5 The role of protein and essential amino acids in the protection against hepatic ischemia-reperfusion injury in mice Manuscript 117
PART III. CLINICAL APPLICATIONS OF DIETARY RESTRICTION 143
Chapter 6 The effects of morbid obesity, metabolic syndrome and bariatric surgery on aging of the T-cell immune system Submitted 145
Chapter 7 Preoperative calorie and protein restriction is feasible and safe in healthy kidney donors and morbidly obese patients: a pilot study Nutrients. 2016 May 20;8(5) 306 167
Chapter 8 Combined calorie and protein restriction improves outcome in living kidney donors and kidney transplant recipients Submitted 199
PART IV SUMMARY AND DISCUSSION 239
Chapter 9 Summary and discussion 241
Chapter 10 Nederlandse samenvatting 259
APPENDICES 271
Dankwoord 273
List of publications 279
Curriculum Vitae 281
PhD portfolio 283

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