Table of Contents I 232

15502-m-pleumeekers

List of abbreviations	6
Introduction	9
Chapter one General introduction	11
Thesis aim and outline	21
Cartilage properties	25
Chapter two Mechanical and biochemical mapping of human auricular cartilage for reliable assessment of tissue-engineered constructs	27
Chapter three Structural and mechanical comparison of human ear, alar and septal cartilage	43
Cell sources	57
Chapter four The in vitro and in vivo capacity of culture-expanded human cells from several sources encapsulated in alginate to form cartilage	59
Chapter five The trophic effect of adipose-tissue-derived and bone-marrowderived mesenchymal stem cells on chondrocytes in co-culture	83
Chapter six Cartilage regeneration in the head and neck area: Combination of ear or nasal chondrocytes and mesenchymal stem cells improves cartilage production	107
Scaffolds	127
Chapter seven Preparation and characterization of a decellularized cartilage scaffold for ear cartilage reconstruction	129
Chapter eight Novel bilayer bacterial nanocellulose scaffold supports neocartilage formation in vitro and in vivo	147
Discussion and summary	173
Chapter nine Discussion and future perspectives for clinical application.	175
Chapter ten Summary	191
Chapter eleven Nederlandse samenvatting	197
References	203
Appendices	221
PhD portfolio	222
Publications	225
Dankwoord	227
Curriculum vitae	231

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