Zhen Li

Chapter 1 General introduction	9
Chapter 2 “Soft” genome editing using CRISPR nickases as a potential source of safer cell products	15
Chapter 3 AAV-vectored base editor trans-splicing delivers dystrophin repair	31
Chapter 4 Precision genome editing using combinatorial viral vector delivery of CRISPR-Cas9 nucleases and donor DNA constructs	39
Chapter 5 Selector AAV-CRISPR vectors purge off-target chromosomal insertions and promote precise genome editing	97
Chapter 6 Summary and general discussion	151
Chapter 7	161
Nederlandse Samenvatting	161
Curriculum Vitae	171
List of Publications	172
Acknowledgements	173

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