Chapter 6 —— 160 —— 23. Kosicki M, Tomberg K, Bradley A. Repair of double-strand breaks induced by CRISPRCas9 leads to large deletions and complex rearrangements. Nat Biotechnol. 2018 36:765771. 24. Chen X, Tasca F, Wang Q, Liu J, Janssen JM, Brescia MD, Bellin M, Szuhai K, Kenrick J, Frock RL, Gonçalves MAFV. Expanding the editable genome and CRISPR-Cas9 versatility using DNA cutting-free gene targeting based on in trans paired nicking. Nucleic Acids Res. 2020 48:974-995. 25. Wang Q, Liu J, Janssen JM, Le Bouteiller M, Frock RL, Gonçalves MAFV. Precise and broad scope genome editing based on high-specificity Cas9 nickases. Nucleic Acids Res. 2021 49:1173-1198. 26. Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H. Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53. Cell Rep. 2020 30:1195-1207.
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