Zhen Li

Chapter 5 —— 147 —— integrate into Cas9-generated double-strand breaks and disrupt gene transcription. Mol. Ther. 2024 S1525-0016(24)00656-7. doi: 10.1016/j.ymthe.2024.09.032. Online ahead of print 26. Schiroli G, Conti A, Ferrari S, Della Volpe L, Jacob A, Albano L, Beretta S, Calabria A, Vavassori V, Gasparini P, Salataj E, Ndiaye-Lobry D, Brombin C, Chaumeil J, Montini E, Merelli I, Genovese P, Naldini L, Di Micco R. Precise Gene Editing Preserves Hematopoietic Stem Cell Function following Transient p53-Mediated DNA Damage Response. Cell Stem Cell. 2019 24:551-565.e8. 27. Allen D, Weiss LE, Saguy A, Rosenberg M, Iancu O, Matalon O, Lee C, Beider K, Nagler A, Shechtman Y, Hendel A. High-Throughput Imaging of CRISPR- and Recombinant Adeno-Associated Virus-Induced DNA Damage Response in Human Hematopoietic Stem and Progenitor Cells. CRISPR J. 2022 5:80-94. 28. Maggio I, Gonçalves MA. Genome editing at the crossroads of delivery, specificity, and fidelity. Trends Biotechnol. 2015 33:280-291. 29. Pavani G, Amendola M. Targeted Gene Delivery: Where to Land. Front Genome Ed. 2021 2:609650. Corrigendum: Front Genome Ed. 2021 3:682171. 30. Spector LP, Tiffany M, Ferraro NM, Abell NS, Montgomery SB, Kay MA. Evaluating the Genomic Parameters Governing rAAV-Mediated Homologous Recombination. Mol Ther. 2021 29:1028-1046. 31. Bijlani S, Pang KM, Sivanandam V, Singh A, Chatterjee S. The Role of Recombinant AAV in Precise Genome Editing. Front Genome Ed. 2022 3:799722. 32. Holkers M, de Vries AA, Gonçalves MA. Nonspaced inverted DNA repeats are preferential targets for homology-directed gene repair in mammalian cells. Nucleic Acids Res. 2012 40:1984-1999. 33. Holkers M, Maggio I, Henriques SF, Janssen JM, Cathomen T, Gonçalves MA. Adenoviral vector DNA for accurate genome editing with engineered nucleases. Nat Methods. 2014 11:1051-1057. 34. Medert R, Thumberger T, Tavhelidse-Suck T, Hub T, Kellner T, Oguchi Y, Dlugosz S, Zimmermann F, Wittbrodt J, Freichel M. Efficient single copy integration via homologydirected repair (scHDR) by 5' modification of large DNA donor fragments in mice. Nucleic Acids Res. 2023 51:e14. 35. Brescia, M., et al., High-Capacity Adenoviral Vectors Permit Robust and Versatile Testing of DMD Gene Repair Tools and Strategies in Human Cells. Cells, 2020 9: 869. 36. Tasca F., Wang Q., Goncalves M Adenoviral vectors meet gene editing: a rising partnership for the genomic engineering of human stem cells and their progeny. Cells. 2020; 9:953.

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