Chapter 3 │ Page 82 Figure 2: Cell survival analysis 24 hours and 48 hours after combination therapy application. NTP significantly improved the cytotoxicity of CDDP in all cell lines, both for the CDDPlow and CDDPhigh condition. E ects became more pronounced over time. Bar plots show intracellular ATP luminescence levels normalized to untreated controls. Data are presented as mean ± SEM (n = 9, 3 independent repeats). Statistical significance for all pairwise comparisons was determined using a linear mixed model analysis with Tukey’s correction for multiple testing. (* p ≤ 0.05; ** p ≤ 0.01; *** p ≤ 0.001; **** p ≤ 0.0001).
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