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Chapter 2 │ Page 61 36. Wende, K., A. Schmidt, and S. Bekeschus, Safety Aspects of Non-Thermal Plasmas, in Comprehensive Clinical Plasma Medicine: Cold Physical Plasma for Medical Application, H.-R. Metelmann, T. von Woedtke, and K.-D. Weltmann, Editors. 2018, Springer International Publishing: Cham. p. 83-109. 37. Lin, A., et al., Non-Equilibrium Dielectric Barrier Discharge Treatment of Mesenchymal Stem Cells: Charges and Reactive Oxygen Species Play the Major Role in Cell Death. Plasma Processes and Polymers, 2015. 12(10): p. 1117-1127. 38. Lin, A., et al., Nanosecond-Pulsed DBD Plasma-Generated Reactive Oxygen Species Trigger Immunogenic Cell Death in A549 Lung Carcinoma Cells through Intracellular Oxidative Stress. International Journal of Molecular Sciences, 2017. 18(5): p. 966. 39. Lin, A., et al., Non-Thermal Plasma as a Unique Delivery System of Short-Lived Reactive Oxygen and Nitrogen Species for Immunogenic Cell Death in Melanoma Cells. Advanced Science, 2019. 0(0): p. 1802062. 40. Liou, G.-Y. and P. Storz, Reactive oxygen species in cancer. Free radical research, 2010. 44(5): p. 479-496. 41. Perillo, B., et al., ROS in cancer therapy: the bright side of the moon. Experimental & Molecular Medicine, 2020. 52(2): p. 192-203. 42. Trzeciak, E.R., et al., Oxidative Stress Di erentially Influences the Survival and Metabolism of Cells in the Melanoma Microenvironment. 2022. 11(6): p. 930. 43. Bekeschus, S., et al., Tumor cell metabolism correlates with resistance to gas plasma treatment: The evaluation of three dogmas. Free Radic Biol Med, 2021. 167: p. 12-28. 44. Schieber, M. and N.S. Chandel, ROS function in redox signaling and oxidative stress. Curr Biol, 2014. 24(10): p. R453-62. 45. Snezhkina, A.V., et al., ROS Generation and Antioxidant Defense Systems in Normal and Malignant Cells. Oxid Med Cell Longev, 2019. 2019: p. 6175804. 46. Moreno, J.A., et al., Fluorescent Orthotopic Mouse Model of Pancreatic Cancer. J Vis Exp, 2016(115). 47. Yuzhakova, D., et al., Highly Invasive Fluorescent/Bioluminescent Patient-Derived Orthotopic Model of Glioblastoma in Mice. Frontiers in Oncology, 2022. 12.

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