Hanne Verswyvel

Chapter 4 │ Page 146 immediately after treatment and 24h later. In contrast, NTP caused a rapid reduction of the two TIGIT ligands CD155 and CD112, and immune checkpoint CD73. Meanwhile, the well-known stress proteins and activating NK cell ligands MICA/B were upregulated 24h after treatment. Taken together, our results demonstrate that NTP a ects di erent ligands important for NK cell functioning, but also that these e ects are dependent on both the specific protein and cellular background. Further research is necessary to broaden our understanding of these e ects. At the same time, expanding the scope of this combined computational and experimental approach to more immune checkpoints will aid in corroborating the immunomodulatory potential of NTP.

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