26 Chapter 2 Table 1 Study characteristics broken down by guideline topic Author, Year Country Design Setting, Single/Multi centre Guideline topic Van den Boogaard, 2009 [27] Netherlands Before-After Hospital - Intensive Care Unit (PICU and Intensive Care Unit) in a tertiary hospital, Single centre Agitation - Delirium Trogrlic, 2019 [28] Netherlands Before-After Hospital - Intensive Care Units in 1University Medical Centre and five community hospitals, Multi centre Agitation - Delirium Pun, 2005 [29] USA Before-After Hospital - Intensive Care Unit wards of the Van der Bilt University Medical Centre in Nashville and the Veterans Administration Tennessee Valley Healthcare System-York Campus, Multi centre Agitation - Delirium and sedation Edwards, 2007 [24] Canada Before-After Hospital and nursing homes - 7 hospitals + 2 home visiting nursing service organisations and one public health unit, Multi centre Combination of multiple guidelines - Asthma, breastfeeding, deliriumdementia-depression, smoking cessation, venous leg ulcers, diabetes Van Gaal (a,b), 2011 [25, 26] Netherlands Cluster Randomized Controlled Trial Hospital and nursing homes - 1 university hospital. 2 large teaching hospitals, one small hospital and 6 nursing homes. 10 hospital wards + 10 Nursing home wards, Multi centre Combination of multiple guidelines - Pressure ulcer, urinary tract infection and falls Seto, 1991 [30] China Before-After Hospital - 6 wards, 3 male, 3 female, Single centre Infection prevention - Catheter associated urinary tract infections Huis, 2013 [31] Netherlands Cluster Randomized Controlled Trial Hospital - 3 hospitals in the Netherlands, Multi centre Infection prevention - hand hygiene Rao, 2009 [32] United Kingdom Cluster Randomized Controlled Trial Nursing home - 12 nursing homes in and surrounding south London, Multi centre Infection prevention - Hand hygiene, environmental and disposal hygiene. Zhu, 2018 [33] China Before-After Hospital - Shanghai Public Health Clinical Centre, Single centre Infection prevention - Nonpharmacological fever management in HIV patients Cabilan, 2014 [34] Australia Before-After Hospital, Single centre Infection prevention - Peripheral cannula infections Frigerio, 2012 [35] Italy Before-After Hospital - 6 Orthopaedic Surgery, 2 Traumatology, 1 Neurosurgery, 1 Neurology, 1 General Surgery, 2 General Medicine, Single centre Infection prevention - Peripheral venous catheter management
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