Caitlin Vink

95 Rational and Design of the MICORDIS study timeframes and risks of the study. Since subjects receive specific instructions regarding their eating habits and medication adjustments may be required prior to their first visit, informed consent is obtained before the first visit. The control group is matched to the patients with respect to sex and age, and are screened for exclusion criteria using TTE, electrocardiography (ECG), and laboratory tests to exclude severe heart disease and impaired renal function. Figure 1. The MICORDIS-study protocol. HE-clamp, hyperinsulinemic-euglycemic clamp; ECFC’s, circulating endothelial colony forming cells; EndoPAT, Peripheral Artery Tonometer 5

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